The present article gives a detailed description of the Manuscript. Title of manuscript is “AVYAYA”. Manuscript was found in Oriental Institute of Baroda. Manuscript has listed several avyaya’s along with their different senses in which they can be used. The present article attempts at simplifying the words of manuscript. Also meanings of avyaya has been provided in English. At last observation has been made on basis of present avyaya studied in paṇini’s grammar.